Search results for "target [nucleus]"
showing 10 items of 78 documents
Biochemical bases for a widespread tolerance of cyanobacteria to the phosphonate herbicide glyphosate
2008
Possible non-target effects of the widely used, non-selective herbicide glyphosate were examined in six cyanobacterial strains, and the basis of their resistance was investigated. All cyanobacteria showed a remarkable tolerance to the herbicide up to millimolar levels. Two of them were found to possess an insensitive form of glyphosate target, the shikimate pathway enzyme 5-enol-pyruvyl-shikimate-3-phosphate synthase. Four strains were able to use the phosphonate as the only phosphorus source. Low uptake rates were measured only under phosphorus deprivation. Experimental evidence for glyphosate metabolism was also obtained in strains apparently unable to use the phosphonate. Results suggest…
Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe
2021
Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA…
Positron emission tomography in CNS drug discovery and drug monitoring.
2014
Molecular imaging methods such as positron emission tomography (PET) are increasingly involved in the development of new drugs. Using radioactive tracers as imaging probes, PET allows the determination of the pharmacokinetic and pharmacodynamic properties of a drug candidate, via recording target engagement, the pattern of distribution, and metabolism. Because of the noninvasive nature and quantitative end point obtainable by molecular imaging, it seems inherently suited for the examination of a pharmaceutical’s behavior in the brain. Molecular imaging, most especially PET, can therefore be a valuable tool in CNS drug research. In this Perspective, we present the basic principles of PET, th…
Relevancia clínica de la selectividad de los inhibidores del cotransportador sodio-glucosa tipo 2
2016
Selectivity is the property of a drug to preferentially bind to a biological structure. Most drugs can bind and stimulate or inhibit more than one system. Therefore, it is important that they are selective for the intended site and that the doses used do not have effects on other sites, which could provoke adverse reactions. Selectivity is assessed through in vitro experiments on organs or isolated cells. If the aim is to compare drugs, the experiment should be conducted in the same tissue and with the same design. Even so, the results cannot be directly extrapolated to clinical practice due to the influence of pharmacokinetic properties, which allow an adequate dose of the drug to reach th…
Sequence variation and regulatory variation in acetylcholinesterase genes contribute to insecticide resistance in different populations of Leptinotar…
2021
Abstract Although insect herbivores are known to evolve resistance to insecticides through multiple genetic mechanisms, resistance in individual species has been assumed to follow the same mechanism. While both mutations in the target site insensitivity and increased amplification are known to contribute to insecticide resistance, little is known about the degree to which geographic populations of the same species differ at the target site in a response to insecticides. We tested structural (e.g., mutation profiles) and regulatory (e.g., the gene expression of Ldace1 and Ldace2, AChE activity) differences between two populations (Vermont, USA and Belchow, Poland) of the Colorado potato beet…
Lower and Upper Bounds of Manufacturing Cost in FMS
1993
Abstract The use of traditional techniques of product costing, cost control and performance evaluation in advanced manufacturing environment supplies poor results to operations management. In this paper, after a brief review of the major drawbacks of traditional machining economics, a new framework for product costing will be presented. The basis of the proposed approach lies on an analysis of the production process aimed at single out proper cost drivers for the use of the various employed manufacturing resources. As a consequence, the quota of the manufacturing cost of uncertain allocation is drastically reduced. A lower and an upper bound value of the unit production cost are also define…
As much English as possible : A study on two secondary school English teachers language use and the motives behind their language choices
2009
Kommunikatiivisen kompetenssin ja suullisen kielitaidon painoarvo vieraiden kielten oppimisessa ja opettamisessa on kasvanut viime vuosina, mikä on lisännyt huomiota myös opettajien kielenkäyttöön. Tämän proseminaaritutkimuksen tarkoituksena oli selvittää, minkä verran englannin opettajat käyttävät tunneillaan englantia ja suomea ja miten he perustelevat kielivalintojaan. Taustana käytettiin teoreettista keskustelua kohdekielen ja äidinkielen hyödyistä kohdekielen oppimisen kannalta sekä aiempia tutkimustuloksia opettajien kielenkäytöstä. Tutkimuksen aineisto koostui kahdesta videokuvatusta kahdeksannen luokan englannin tunnista ja tunnit pitäneiden opettajien haastatteluista. Toisella ope…
La remontée du saumon pour le frai dans le fleuve Tornionjoki, suivie au moyen d'un sonar à double faisceau horizontal.
2000
Fixed location split-beam horizontal echosounding was used to assess the size and timing of the Atlantic salmon (Salmo salar) spawning run in the River Tornionjoki. Four transducers, two on each river bank, were mounted across the river at the study site 4 km upstream from the river mouth. Net weirs were used on both shores to direct the passage of fish through the acoustic beams. Hydroacoustic monitoring covered 40-50% of the river cross-sectional area. Also test fishing and yearly catch statistics of salmon were used as an indication of the size of the spawning run in the river. Altogether, 7 700, 5 300 and 4 300 salmon-sized targets (target strength, TS ≥ -29 dB) moving upstream were det…
“The Olympic Torch Burns, and Great Suspicion Blazes” – China Narratives in the German Media during the 2008 Summer Olympics in Beijing
2009
This paper focuses on the description of China in leading German daily and weekly newspapers during the 2008 Summer Olympics in Beijing. On the basis of a brief outline of the main China narratives in German media since the 1950s, this paper analyses China-related articles which were published during the period August 8–15, 2008. It argues that reports on China are mostly based on well established German notions of China and centre around the image of a despotic and/or dangerous China. Therefore, they primarily refer back to the source culture and contain little information of value regarding the target culture.
RELAP5-3D thermal hydraulic analysis of the target cooling system in the SPES experimental facility
2014
The SPES (Selective Production of Exotic Species) experimental facility, under construction at the Italian National Institute of Nuclear Physics (INFN) Laboratories of Legnaro, Italy, is a second generation Isotope Separation On Line (ISOL) plant for advanced nuclear physic studies. The UCx target-ion source system works at temperature of about 2273 K, producing a high level of radiation (10^5 Sv/h), for this reason a careful risk analysis for the target chamber is among the major safety issues. In this paper, the obtained results of thermofluid-dynamics simulations of accidental transients in the SPES target cooling system are reported. The analysis, performed by using the RELAP5-3D 2.4.2 …